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体外方法比较标的结合和CDC诱导治疗性抗体之间:应用在Biosimilarity分析
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
DOI:

07:25 min

May 04, 2017

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Chapters

  • 00:05Title
  • 00:48Flow Cytometric Target Binding Analysis
  • 03:35Complement-dependent Cytotoxicity (CDC) Assessment
  • 05:29Results: Representative Anti-CD20 Therapeutic Monoclonal Antibody Analyses
  • 06:38Conclusion

Summary

Automatic Translation

该协议描述了利妥昔单抗的两个关键功能特征的体外比较:靶结合和补体依赖性细胞毒性(CDC)诱导。该方法用于参考利妥昔单抗和利妥昔单抗生物仿制药之间的对侧比较。这些测定可以在生物仿制发展过程中使用或作为其生产中的质量控制。

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