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磁気共鳴ガイド下高強度集束超音波生成温熱療法:マウス横紋筋肉腫モデルにおける実行可能な治療法
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JoVE Journal
Cancer Research
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
Please note that all translations are automatically generated.
Click here for the English version.
磁気共鳴ガイド下高強度集束超音波生成温熱療法:マウス横紋筋肉腫モデルにおける実行可能な治療法
DOI:
10.3791/64544-v
•
13:41 min
•
January 13, 2023
•
Claire Wunker
2
,
Karolina Piorkowska
,
Ben Keunen
,
Yael Babichev
,
Suzanne M. Wong
4
,
Maximilian Regenold
,
Michael Dunne
,
Julia Nomikos
2
,
Maryam Siddiqui
,
Samuel Pichardo
,
Warren Foltz
,
Adam C. Waspe
8
,
Justin T. Gerstle
9
,
James M. Drake
3,4,10
,
Rebecca A. Gladdy
2,10
1
Institute of Medical Science
,
University of Toronto
,
2
Lunenfeld-Tanenbaum Research Institute
,
Mount Sinai Hospital
,
3
The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention
,
The Hospital for Sick Children
,
4
Institute of Biomedical Engineering
,
University of Toronto
,
5
Leslie Dan Faculty of Pharmacy
,
University of Toronto
,
6
Departments of Radiology and Clinical Neurosciences
,
University of Calgary
,
7
Department of Radiation Oncology
,
University of Toronto
,
8
Department of Medical Imaging
,
University of Toronto
,
9
Department of Pediatric Surgery
,
University of Toronto
,
10
Department of Surgery
,
University of Toronto
Chapters
00:04
Introduction
01:11
Intramuscular Cell Injection
02:08
Screening MRI Scan and HIFU Treatment
10:46
Results: Average Temperatures and Success Rates of Hyperthermia Treatment and Doxorubicin Levels in the Tumor
13:03
Conclusion
Summary
Automatic Translation
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Automatic Translation
ここに提示されるのは、横紋筋肉腫マウスモデルにおいて温度感受性リポソームからの薬物放出を引き起こすために、磁気共鳴ガイド下高強度集束超音波によって生成される制御された温熱療法を使用するプロトコルです。
Tags
Magnetic Resonance
High Intensity Focused Ultrasound
Hyperthermia
Rhabdomyosarcoma
Preclinical Testing
Tumor Targeted
Thermosensitive Drugs
Sarcoma
Localized Hypothermia
Immune System
MRI
HIFU
Mouse Model
Tumor Growth
Imaging
Transducer
Deionized Water
Anesthesia
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