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Cancer Research
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磁共振引导的高强度聚焦超声产生热疗:小鼠横纹肌肉瘤模型中的可行治疗方法
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Cancer Research
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JoVE Journal
Cancer Research
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
Please note that all translations are automatically generated.
Click here for the English version.
磁共振引导的高强度聚焦超声产生热疗:小鼠横纹肌肉瘤模型中的可行治疗方法
DOI:
10.3791/64544-v
•
13:41 min
•
January 13, 2023
•
Claire Wunker
2
,
Karolina Piorkowska
,
Ben Keunen
,
Yael Babichev
,
Suzanne M. Wong
4
,
Maximilian Regenold
,
Michael Dunne
,
Julia Nomikos
2
,
Maryam Siddiqui
,
Samuel Pichardo
,
Warren Foltz
,
Adam C. Waspe
8
,
Justin T. Gerstle
9
,
James M. Drake
3,4,10
,
Rebecca A. Gladdy
2,10
1
Institute of Medical Science
,
University of Toronto
,
2
Lunenfeld-Tanenbaum Research Institute
,
Mount Sinai Hospital
,
3
The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention
,
The Hospital for Sick Children
,
4
Institute of Biomedical Engineering
,
University of Toronto
,
5
Leslie Dan Faculty of Pharmacy
,
University of Toronto
,
6
Departments of Radiology and Clinical Neurosciences
,
University of Calgary
,
7
Department of Radiation Oncology
,
University of Toronto
,
8
Department of Medical Imaging
,
University of Toronto
,
9
Department of Pediatric Surgery
,
University of Toronto
,
10
Department of Surgery
,
University of Toronto
Chapters
00:04
Introduction
01:11
Intramuscular Cell Injection
02:08
Screening MRI Scan and HIFU Treatment
10:46
Results: Average Temperatures and Success Rates of Hyperthermia Treatment and Doxorubicin Levels in the Tumor
13:03
Conclusion
Summary
Automatic Translation
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Automatic Translation
这里介绍的是一种协议,使用由磁共振引导的高强度聚焦超声产生的受控热疗来触发横纹肌肉瘤小鼠模型中温度敏感脂质体的药物释放。
Tags
Magnetic Resonance
High Intensity Focused Ultrasound
Hyperthermia
Rhabdomyosarcoma
Preclinical Testing
Tumor Targeted
Thermosensitive Drugs
Sarcoma
Localized Hypothermia
Immune System
MRI
HIFU
Mouse Model
Tumor Growth
Imaging
Transducer
Deionized Water
Anesthesia
Article
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