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Cancer Research
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急性リンパ芽球性白血病患者由来異種移植マウスモデルを用いたキメラ抗原受容体T細胞関連毒性の評価
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JoVE Journal
Cancer Research
Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Please note that all translations are automatically generated.
Click here for the English version.
急性リンパ芽球性白血病患者由来異種移植マウスモデルを用いたキメラ抗原受容体T細胞関連毒性の評価
DOI:
10.3791/64535-v
•
06:08 min
•
February 10, 2023
•
Claudia Manriquez Roman
2,3,4,5
,
R. Leo Sakemura
2
,
Brooke L. Kimball
2
,
Fang Jin
,
Roman H. Khadka
,
Mohamad M. Adada
2
,
Elizabeth L. Siegler
2
,
Aaron J. Johnson
,
Saad S. Kenderian
2,6
1
T Cell Engineering Laboratory
,
Mayo Clinic, Rochester
,
2
Division of Hematology
,
Mayo Clinic, Rochester
,
3
Mayo Clinic Graduate School of Biomedical Sciences
,
Mayo Clinic, Rochester
,
4
Department of Molecular Medicine
,
Mayo Clinic, Rochester
,
5
Regenerative Sciences PhD Program
,
Mayo Clinic, Rochester
,
6
Department of Immunology
,
Mayo Clinic, Rochester
Chapters
00:04
Introduction
00:49
Assessment of CART19 Cell‐Associated Toxicities
01:33
MRI Imaging
04:02
Results: Assessment of CART Cell‐Associated Toxicities in a PDX Mice Model
05:17
Conclusion
Summary
Automatic Translation
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Automatic Translation
ここでは、急性リンパ芽球性白血病患者由来の異種移植片モデルを、CD19標的キメラ抗原受容体T細胞関連毒性を評価および監視するための戦略として使用するプロトコルについて説明します。
Tags
CAR-T
Acute Lymphoblastic Leukemia
Patient-derived Xenograft
Toxicity Assessment
Motor Weakness
Weight Loss
Cytokine Analysis
MRI Imaging
Breathing Monitoring
ParaVision Software
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