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Cancer Research
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使用急性淋巴细胞白血病患者来源的异种移植小鼠模型评估嵌合抗原受体T细胞相关毒性
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JoVE Journal
Cancer Research
Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Please note that all translations are automatically generated.
Click here for the English version.
使用急性淋巴细胞白血病患者来源的异种移植小鼠模型评估嵌合抗原受体T细胞相关毒性
DOI:
10.3791/64535-v
•
06:08 min
•
February 10, 2023
•
Claudia Manriquez Roman
2,3,4,5
,
R. Leo Sakemura
2
,
Brooke L. Kimball
2
,
Fang Jin
,
Roman H. Khadka
,
Mohamad M. Adada
2
,
Elizabeth L. Siegler
2
,
Aaron J. Johnson
,
Saad S. Kenderian
2,6
1
T Cell Engineering Laboratory
,
Mayo Clinic, Rochester
,
2
Division of Hematology
,
Mayo Clinic, Rochester
,
3
Mayo Clinic Graduate School of Biomedical Sciences
,
Mayo Clinic, Rochester
,
4
Department of Molecular Medicine
,
Mayo Clinic, Rochester
,
5
Regenerative Sciences PhD Program
,
Mayo Clinic, Rochester
,
6
Department of Immunology
,
Mayo Clinic, Rochester
Chapters
00:04
Introduction
00:49
Assessment of CART19 Cell‐Associated Toxicities
01:33
MRI Imaging
04:02
Results: Assessment of CART Cell‐Associated Toxicities in a PDX Mice Model
05:17
Conclusion
Summary
Automatic Translation
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Automatic Translation
在这里,我们描述了一种方案,其中使用急性淋巴细胞白血病患者来源的异种移植模型作为评估和监测CD19靶向嵌合抗原受体T细胞相关毒性的策略。
Tags
CAR-T
Acute Lymphoblastic Leukemia
Patient-derived Xenograft
Toxicity Assessment
Motor Weakness
Weight Loss
Cytokine Analysis
MRI Imaging
Breathing Monitoring
ParaVision Software
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