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Cancer Research
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多形性胶质母细胞瘤的转化原位模型
JoVE Journal
Cancer Research
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JoVE Journal
Cancer Research
Translational Orthotopic Models of Glioblastoma Multiforme
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多形性胶质母细胞瘤的转化原位模型
DOI:
10.3791/64482-v
•
07:37 min
•
February 17, 2023
•
Rajaa El Meskini
,
Devon Atkinson
,
Zoë Weaver Ohler
1
Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research
,
National Cancer Institute
Chapters
00:04
Introduction
01:23
Surgical Area and Mouse Preparation
03:34
Cell Injection, Needle Removal, and Wound Closure
05:53
Results: Assessment of an Orthotopic Mouse Tumor Model for Human Glioblastoma Multiforme
06:55
Conclusion
Summary
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在这里,我们描述了GBM的临床前原位小鼠模型,该模型是通过颅内注射源自基因工程小鼠模型肿瘤的细胞而建立的。该模型显示了人类GBM的疾病特征。对于转化研究,通过
体内
MRI和组织病理学跟踪小鼠脑肿瘤。
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