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全层软骨缺损大鼠模型的开发与评价
JoVE Journal
Medicine
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JoVE Journal
Medicine
Development and Evaluation of a Rat Model of Full-Thickness Cartilage Defects
Please note that all translations are automatically generated.
Click here for the English version.
全层软骨缺损大鼠模型的开发与评价
DOI:
10.3791/64475-v
•
04:34 min
•
May 19, 2023
•
Haiyan Zhang*
1
,
Ronghua Bao*
2
,
Jiaan Xu
,
Yanzhi Ge
,
Zuxiang Chen
,
Mengqiang Fan
,
Guangping Yu
,
Li Zhou
,
Le Guo
,
Letian Shan
,
Hangxing Bao
1
The First Affiliated Hospital
,
Zhejiang Chinese Medical University
,
2
Fuyang Orthopaedics and Traumatology Affiliated Hospital
,
Zhejiang Chinese Medical University
,
3
College of Pharmaceutical Science
,
Zhejiang Chinese Medical University
,
4
Affiliated Zhejiang Hospital
,
Zhejiang University School of Medicine
,
5
Xianju County Hospital of Chinese Medicine
Chapters
00:04
Introduction
01:18
Establishment of Murine Full‐Thickness Cartilage Defects Model
02:27
Measurement of Mechanical Withdrawal Threshold
03:12
Results: Comparative Analysis of Mechanical Withdrawal Threshold in Murine Models
04:10
Conclusion
Summary
Automatic Translation
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Automatic Translation
该协议通过在大鼠的股骨滑车沟中钻孔并测量随后的疼痛行为和组织病理学变化来建立全层软骨缺陷(FTCD)模型。
Tags
Rat Model
Full-thickness Cartilage Defects
FTCD
Traumatic Cartilage Defects
Post-traumatic Osteoarthritis
Cartilage Injury
Animal Model
Cartilage Defect Evaluation
Mechanical Withdrawal Threshold
Hyperalgesia
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