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通过颈内动脉注射癌细胞模拟脑转移
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
DOI:

10:01 min

August 02, 2022

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Chapters

  • 00:04Introduction
  • 01:06Preparation of Cancer Cells for Injection
  • 03:01Preparation of the Mouse for the Procedure
  • 04:06Internal Carotid Injection and Post-Injection Recovery
  • 07:44Results: Generation of Brain Metastasis Murine Model for Screening and Evaluating the Therapeutic Profile of Drugs
  • 09:23Conclusion

Summary

Automatic Translation

脑转移是癌症患者严重发病和死亡的原因。大多数脑转移小鼠模型因全身转移而复杂化,混淆死亡率和治疗干预结果的分析。这里介绍的是颈动脉内注射癌细胞的方案,该方案产生一致的颅内肿瘤和最小的全身性肿瘤。

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