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通过颈内动脉注射癌细胞模拟脑转移
JoVE Journal
Cancer Research
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JoVE Journal
Cancer Research
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
Please note that all translations are automatically generated.
Click here for the English version.
通过颈内动脉注射癌细胞模拟脑转移
DOI:
10.3791/64216-v
•
10:01 min
•
August 02, 2022
•
Malcolm Lim
,
Nicholas Fletcher
,
Amy McCart Reed
,
Melanie Flint
,
Kristofer Thurecht
,
Jodi Saunus*
1,4
,
Sunil R. Lakhani*
1,5
1
UQ Centre for Clinical Research
,
The University of Queensland
,
2
Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology and ARC Training Centre for Innovation in Biomedical Imaging Technology
,
The University of Queensland
,
3
School of Biomedical Sciences
,
The University of Queensland
,
4
Mater Research and Mater Research Institute
,
The University of Queensland
,
5
Pathology Queensland
,
Royal Brisbane Women’s Hospital
Chapters
00:04
Introduction
01:06
Preparation of Cancer Cells for Injection
03:01
Preparation of the Mouse for the Procedure
04:06
Internal Carotid Injection and Post-Injection Recovery
07:44
Results: Generation of Brain Metastasis Murine Model for Screening and Evaluating the Therapeutic Profile of Drugs
09:23
Conclusion
Summary
Automatic Translation
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Automatic Translation
脑转移是癌症患者严重发病和死亡的原因。大多数脑转移小鼠模型因全身转移而复杂化,混淆死亡率和治疗干预结果的分析。这里介绍的是颈动脉内注射癌细胞的方案,该方案产生一致的颅内肿瘤和最小的全身性肿瘤。
Tags
Brain Metastasis
Internal Carotid Artery Injection
Cancer Cells
Mouse Model
BT-474 Cells
Cell Culture
Cell Preparation
Cell Injection
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