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Niet-invasieve PET/MR-beeldvorming in een orthotopisch muismodel van hepatocellulair carcinoom
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1Department of Diagnostic Radiology, School of Clinical Medicine, LKS Faculty of Medicine,The University of Hong Kong, 2Department of Oncology, MRC Oxford Institute for Radiation Oncology,University of Oxford, 3Department of Surgery, School of Clinical Medicine, HKU-SZH & LKS Faculty of Medicine,The University of Hong Kong, 4Department of Biomedical Engineering,The Chinese University of Hong Kong, 5Department of Diagnostic and Interventional Radiology,Kwong Wah Hospital
Chapters
- 00:04Introduction
- 01:06Subcutaneous Injection of Human Hepatocellular Carcinoma Cell Lines
- 01:45Orthotopic Liver Implantation and Hepatic Artery Ligation
- 04:00[18F] FMISO and [18F] FDG Injection
- 04:42PET/MR Acquisition
- 05:57Results: Effect of Hepatic Artery Ligation on Orthotopic Hepatocellular Carcinoma in Mice
- 07:02Conclusion
Hier presenteren we een protocol om orthotopische hepatocellulaire carcinoom xenografts met en zonder ligatie van de leverslagader te creëren en niet-invasieve positronemissietomografie (PET) beeldvorming van tumorhypoxie uit te voeren met behulp van [18 F] Fluoromisonidazol ([18 F] FMISO) en [18 F] Fluorodeoxyglucose ([18F] FDG).
