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Medicine
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マウス心臓における光遺伝学的マルチサイト光刺激の適用による高度な心調律管理
JoVE Journal
Medicine
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JoVE Journal
Medicine
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
Please note that all translations are automatically generated.
Click here for the English version.
マウス心臓における光遺伝学的マルチサイト光刺激の適用による高度な心調律管理
DOI:
10.3791/62335-v
•
08:43 min
•
August 26, 2021
•
Laura Diaz-Maue*
1,2
,
Janna Steinebach*
1
,
Michael Schwaerzle
9
,
Stefan Luther
3,4,6
,
Patrick Ruther
9
,
Claudia Richter
5,6,7
1
Research Group Biomedical Physics
,
Max Planck Institute for Dynamics and Self-Organization
,
2
Research Electronics Department
,
Max Planck Institute for Dynamics and Self-Organization
,
3
Department of Pharmacology and Toxicology
,
University Medical Center Goettingen
,
4
Institute for Nonlinear Dynamics
,
Georg-August-University Goettingen
,
5
Department of Cardiology and Pneumology
,
University Medical Center Goettingen
,
6
German Center for Cardiovascular Research
,
DZHK e.V., partner site Goettingen
,
7
Laboratory Animal Science Unit
,
German Primate Center Leibniz Institute for Primate Research
,
8
Department of Microsystems Engineering (IMTEK)
,
University of Freiburg
,
9
Cluster of Excellence BrainLinks-BrainTools
,
University of Freiburg
Chapters
00:04
Introduction
00:54
Langendorff Perfusion
02:53
Arrhythmia Induction and Optical Defibrillation
04:41
Optical Mapping
05:45
Results: Analysis of Success Rates and Manipulation of Cardiac Rhythm by Means of Photosimulation
07:56
Conclusion
Summary
Automatic Translation
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Automatic Translation
本研究では、トランスジェニックチャネルロドプシン-2(ChR2)マウスの無傷マウス心臓の心調律を、マイクロLEDアレイによる局所光刺激と心外膜電位の同時光学マッピングを用いて制御する方法を報告する。
Tags
Optogenetics
Cardiac Rhythm Management
Multi-site Photostimulation
Murine Hearts
Cardiac Fibrillation
Defibrillation
Micro LED Array
ECG
Thyroid Solution
Perfusion System
Cardiac Arrhythmia
Large Animal Models
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