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1Research Group Biomedical Physics,Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department,Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology,University Medical Center Goettingen, 4Institute for Nonlinear Dynamics,Georg-August-University Goettingen, 5Department of Cardiology and Pneumology,University Medical Center Goettingen, 6German Center for Cardiovascular Research,DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit,German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK),University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools,University of Freiburg
Chapters
- 00:04Introduction
- 00:54Langendorff Perfusion
- 02:53Arrhythmia Induction and Optical Defibrillation
- 04:41Optical Mapping
- 05:45Results: Analysis of Success Rates and Manipulation of Cardiac Rhythm by Means of Photosimulation
- 07:56Conclusion
Ce travail rapporte une méthode pour contrôler le rythme cardiaque de cœurs murins intacts de souris transgéniques channelrhodopsin-2 (ChR2) en utilisant la photostimulation locale avec un réseau micro-LED et la cartographie optique simultanée du potentiel de membrane épicardique.
