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Cancer Research
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転移率を制御する切断を用いた同種異形性骨肉腫スプレイグ・ドーリーラットモデル
JoVE Journal
Cancer Research
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JoVE Journal
Cancer Research
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Please note that all translations are automatically generated.
Click here for the English version.
転移率を制御する切断を用いた同種異形性骨肉腫スプレイグ・ドーリーラットモデル
DOI:
10.3791/62139-v
•
07:31 min
•
May 03, 2021
•
Shun Ishiyama
2,3,4
,
Casey Kissel
,
Xin Guo
,
Alexis Howard
,
Harumi Saeki
,
Tomoaki Ito
,
Polina Sysa-Shah
,
Hajime Orita
,
Kazuhiro Sakamoto
,
Kathleen Gabrielson
2
1
Department of Molecular and Comparative Pathobiology
,
The Johns Hopkins University School of Medicine
,
2
Sidney Kimmel Comprehensive Cancer Center
,
Johns Hopkins University
,
3
Department of Surgery
,
Johns Hopkins University School of Medicine
,
4
Department of Coloproctological Surgery
,
Juntendo University Faculty of Medicine
,
5
Program for Comparative Medicine, Gene Therapy Program, Perelman School of Medicine
,
University of Pennsylvania
,
6
Tuskegee College of Veterinary Medicine
,
7
Department of Human Pathology
,
Juntendo University Faculty of Medicine
,
8
Department of Surgery, Juntendo University Shizuoka Hospital
,
Juntendo University School of Medicine
,
9
Department of Urology
,
The Johns Hopkins School of Medicine
,
10
Department of Gastroenterology and Minimally Invasive Surgery
,
Juntendo University Faculty of Medicine
Chapters
00:04
Introduction
01:19
Intratibial Osteosarcoma (OS) Cell Injection
02:41
Doxorubicin Intravenous Administration
03:36
Hind Limb Amputation
05:08
Results: Representative Rat OS Imaging and Analysis
06:43
Conclusion
Summary
Automatic Translation
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Automatic Translation
ここでは、転移生物学の前臨床調査や新規治療薬の開発に使用できる自発的な肺転移を伴う骨肉腫の切断手順に続く同種の同一性の好交性移植法について説明する。
Tags
Syngeneic Orthotopic Osteosarcoma
Sprague Dawley Rat Model
Amputation
Lung Metastasis
Jugular Vein Injection
Nanoparticle Delivery
Radiolabeled Ligand
Limb Amputation
Tibia Injection
Tumor Cell Implantation
Doxorubicin Administration
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