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Ein syngenes orthotopes Osteosarkom Sprague Dawley Rattenmodell mit Amputation zur Kontrolle der Metastasenrate
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1Department of Molecular and Comparative Pathobiology,The Johns Hopkins University School of Medicine, 2Sidney Kimmel Comprehensive Cancer Center,Johns Hopkins University, 3Department of Surgery,Johns Hopkins University School of Medicine, 4Department of Coloproctological Surgery,Juntendo University Faculty of Medicine, 5Program for Comparative Medicine, Gene Therapy Program, Perelman School of Medicine,University of Pennsylvania, 6Tuskegee College of Veterinary Medicine, 7Department of Human Pathology,Juntendo University Faculty of Medicine, 8Department of Surgery, Juntendo University Shizuoka Hospital,Juntendo University School of Medicine, 9Department of Urology,The Johns Hopkins School of Medicine, 10Department of Gastroenterology and Minimally Invasive Surgery,Juntendo University Faculty of Medicine
Chapters
- 00:04Introduction
- 01:19Intratibial Osteosarcoma (OS) Cell Injection
- 02:41Doxorubicin Intravenous Administration
- 03:36Hind Limb Amputation
- 05:08Results: Representative Rat OS Imaging and Analysis
- 06:43Conclusion
Hier wird eine syngene orthotope Implantation gefolgt von einem Amputationsverfahren des Osteosarkoms mit spontaner Lungenmetastasierung beschrieben, das zur präklinischen Untersuchung der Metastasenbiologie und entwicklung neuartiger Therapeutika eingesetzt werden kann.
