A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:05Title
- 02:08Orthotopic Xenograft Implantation
- 07:41Bioluminescent Imaging (BLI) to Monitor Tumor Growth and Response to Therapy
- 08:38Results: In Vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme
- 09:52Conclusion
Wir beschreiben eine integrierte Methode für die präzise, stereotaktische Implantation von humanen Glioblastom multiforme Zellen in den Gehirnen von Nacktmäusen und anschließende serielle<em> In vivo</em> Bildgebung zu überwachen und Wachstum Ansprechen auf die Behandlung der resultierenden Xenotransplantate.
Tags
Stereotactic Intracranial ImplantationIn Vivo Bioluminescent ImagingTumor XenograftsMouse Model SystemGlioblastoma MultiformeHigh-grade Primary Brain CancerMedian SurvivalStandard Tri-modality TreatmentSurgical ResectionRadiation TherapyTemozolomide ChemotherapyTherapeutic ApproachesAnimal ModelsTumor GrowthTreatment ResponseBio-imageable GBM Cancer CellsNude MiceAnatomic LocationsIn Vivo Bioluminescent ImagingIntracranial Xenograft GrowthPerioperative MorbidityMortality
