Journal
/
Medicine
/
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
JoVE Journal
Medicine
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Medicine
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

DOI:
10.3791/65071-v

•

11:06 min

•

April 07, 2023

•

, , , , , , ,
1School of Health Preservation and Rehabilitation,Chengdu University of Traditional Chinese Medicine, 2State Administration of Traditional Chinese Medicine Key Laboratory of Traditional Chinese Medicine, Regimen and Health,Chengdu University of Traditional Chinese Medicine, 3Key Laboratory of Traditional Chinese Medicine Regimen and Health of Sichuan Province

Chapters

  • 00:04Introduction
  • 00:52Network Pharmacology-Based Prediction
  • 04:52Metabolomic Validation
  • 06:03Molecular Docking
  • 08:11Results: Network Pharmacology Prediction and Metabolomics Validation
  • 10:36Conclusion

Summary

Automatic Translation

Automatic Translation

The present protocol describes an integrated strategy for exploring the key targets and mechanisms of Fructus Phyllanthi against hyperlipidemia based on network pharmacology prediction and metabolomics verification.

Tags

Network PharmacologyMetabolomicsFructus PhyllanthiHyperlipidemiaActive IngredientsKey TargetsProtein-protein Interaction NetworkDrug-component-disease Target NetworkHub GenesTraditional Chinese MedicineSystems Pharmacology

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Harvest of Endothelial Cells from the Balloon Tips of Swan-Ganz Catheters after Right Heart Catheterization

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Read Article