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Immunology and Infection
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慢性肝纤维化小鼠模型用于研究胆道闭锁
JoVE Journal
Immunology and Infection
This content is Free Access.
JoVE Journal
Immunology and Infection
A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
Please note that all translations are automatically generated.
Click here for the English version.
慢性肝纤维化小鼠模型用于研究胆道闭锁
DOI:
10.3791/65044-v
•
09:12 min
•
February 03, 2023
•
Xinrui Wang
2
,
Ruizhong Zhang
,
Zefeng Lin
,
Ming Fu
,
Yan Chen
2
1
School of Medicine
,
South China University of Technology
,
2
Provincial Key Laboratory of Research in Structure Birth Defect Disease and Department of Pediatric Surgery
,
Guangzhou Women and Children’s Medical Center
Chapters
00:04
Introduction
00:50
Establishment of the Chronic Fibrotic BA Mouse Model
01:45
Intraperitoneal Injection of the Mice
02:36
Collection of Sample Tissue
03:13
Fluorescein Angiography of the Extrahepatic Bile Duct
03:41
H&E Staining
04:43
CK19 and F4/80 Immunohistochemical Staining
06:00
Sirius Red Staining
06:55
Results: Effects of Anti‐Ly6G Antibody Treatment in a Mouse Model of Biliary Atresia (BA) Infected with RRV
08:42
Conclusion
Summary
Automatic Translation
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Automatic Translation
我们建立了慢性肝纤维化小鼠模型,为病毒诱导的胆道闭锁(BA)肝纤维化机制研究提供了合适的动物模型,并为未来的BA治疗提供了平台。
Tags
Mouse Model
Chronic Liver Fibrosis
Biliary Atresia
Rhesus Rotavirus
Anti-Ly6G Antibody
Intraperitoneal Injection
Liver Function
Fluorescent Dye
Gallbladder
Extrahepatic Bile Ducts
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