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小鼠患者来源的癌细胞原位植入概括了晚期结直肠癌
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Cancer Research
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JoVE Journal Cancer Research
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
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小鼠患者来源的癌细胞原位植入概括了晚期结直肠癌

DOI:
10.3791/64629-v

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06:49 min

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February 10, 2023

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, , ,
1Stem Cells and Cancer Laboratory,Vall d’Hebron Institute of Oncology (VHIO), 2Preclinical Therapeutics Core,University of California San Francisco, 3CIBERONC

Chapters

  • 00:05Introduction
  • 00:54Derivation of Patient Cells
  • 03:37Orthotopic Injection in Cecum
  • 05:27Results: Histological Analysis of Orthotopic CRC-PDX Tumors and Therapeutic Efficacy of a Testing Drug
  • 06:26Conclusion

Summary

Automatic Translation

Automatic Translation

该方案描述了在免疫缺陷小鼠盲肠壁中将患者来源的癌细胞原位植入。该模型概括了晚期结直肠癌转移性疾病，并允许在肺和肝转移的临床相关情况下评估新的治疗药物。

Tags

Orthotopic ImplantationPatient-derived Cancer CellsColorectal CancerAdvanced Metastatic DiseaseMouse ModelCell DissociationCell SortingCell ResuspensionCecum Injection

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