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间变性甲状腺癌和头颈部鳞状细胞癌患者来源异种移植模型的建立与表征
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Cancer Research
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JoVE Journal Cancer Research
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
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间变性甲状腺癌和头颈部鳞状细胞癌患者来源异种移植模型的建立与表征

DOI:
10.3791/64623-v

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06:08 min

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June 02, 2023

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, , , , , , , , ,
1Precision Medicine Research Center, Sichuan Provincial Key Laboratory of Precision Medicine, National Clinical Research Center for Geriatrics, West China Hospital,Sichuan University, 2Department of Thyroid Surgery, West China Hospital,Sichuan University, 3Sichuan Kangcheng Biotech Co., 4Sichuan Cancer Hospital

Chapters

  • 00:04Introduction
  • 01:03Tumor Transplantation and Preservation
  • 02:49Resuscitation of Patient-Derived Xenograft (PDX) Model Tumors
  • 03:57Results: Tumor Growth Assessment & Effect of Lenvatinib and Cisplatin on PDX Model Tumors
  • 05:28Conclusion

Summary

Automatic Translation

Automatic Translation

由于PDX模型正在迅速成为转化肿瘤学领域的标准，因此本协议建立并表征了间变性甲状腺癌（ATC）和头颈部鳞状细胞癌（HNSCC）的患者来源异种移植（PDX）模型。

Tags

Patient-derived XenograftPDXAnaplastic Thyroid CarcinomaATCHead And Neck Squamous Cell CarcinomaHNSCCTumor HeterogeneityMolecular DiversityPersonalized TreatmentAnti-cancer Drug Sensitivity ScreeningTumor TransplantationSubcutaneousCryopreservationTumor Growth Curve

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