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使用轻度创伤性脑损伤的清醒闭合性头部损伤模型评估突触可塑性的变化
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Neuroscience
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JoVE Journal Neuroscience
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
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使用轻度创伤性脑损伤的清醒闭合性头部损伤模型评估突触可塑性的变化

DOI:
10.3791/64592-v

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09:49 min

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January 20, 2023

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, , , , , , , ,
1Division of Medical Sciences,University of Victoria, 2Island Medical Program,University of British Columbia

Chapters

  • 00:04Introduction
  • 01:01Induction of Mild Traumatic Brain Injuries (mTBI)
  • 02:10Slice Preparation
  • 04:09Field Electrophysiology
  • 07:36Results: Effects of Repeated Mild Traumatic Brain Injury (r-mTBI) on Synaptic Plasticity in the Hippocampus
  • 09:02Conclusion

Summary

Automatic Translation

Automatic Translation

在这里，展示了如何使用清醒闭合性头部损伤模型来检查反复轻度创伤性脑损伤（r-mTBI）对海马突触可塑性的影响。该模型在患者中复制了r-mTBI的重要特征，并与 体外 电生理学结合使用。

Tags

Synaptic PlasticityAwake Closed-head Injury ModelMild Traumatic Brain Injury (mTBI)Transverse Hippocampal SlicesNeurological Assessment Protocol (NAP)Electrophysiological RecordingsBrain DissectionSlice Preparation

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