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侵入斑马鱼大脑的胶质母细胞瘤细胞微管动力学的实时成像
JoVE Journal
Biology
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JoVE Journal Biology
Live Imaging of Microtubule Dynamics in Glioblastoma Cells Invading the Zebrafish Brain
DOI:

09:29 min

July 29, 2022

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Chapters

  • 00:04Introduction
  • 01:03Xenotransplantation Procedure
  • 04:46Intravital Imaging of the Glioblastoma Xenografts
  • 07:41Results: Understanding Microtubule Dynamics of Glioblastoma Cells via Live Imaging of Zebrafish Larval Xenografts
  • 08:53Conclusion

Summary

Automatic Translation

我们报告了一种允许对侵入脊椎动物脑组织的胶质母细胞瘤(GBM)细胞中的微管动力学进行实时成像的技术。将荧光标记的GBM细胞的原位注射耦合到具有高分辨率活体成像的透明斑马鱼脑中,可以在 原位 癌症侵袭期间测量细胞骨架动力学。

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