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油酸诱导的急性呼吸窘迫综合征小鼠模型
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
DOI:

04:45 min

June 02, 2022

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Chapters

  • 00:04Introduction
  • 01:06Preparation of Sodium Oleate Solution and Induction of Lung Injury by Oleic Acid
  • 02:15Bronchoalveolar Lavage Fluid (BALF) Collection
  • 02:59Results: Lung Injury Mouse Model for Acute Respiratory Distress Syndrome
  • 04:05Conclusion

Summary

Automatic Translation

本方案描述了使用油酸模拟急性呼吸窘迫综合征(ARDS)的小鼠肺损伤模型。该模型增加了水肿的炎症介质并降低了肺顺应性。油酸以盐形式(油酸盐)使用,因为这种生理形式避免了栓塞的风险。

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