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膀胱癌类器官作为精准医疗工具的文化

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Cancer Research

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JoVE Journal Cancer Research

Culture of Bladder Cancer Organoids as Precision Medicine Tools

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膀胱癌类器官作为精准医疗工具的文化

DOI:

10.3791/63192-v

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08:39 min

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December 28, 2021

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Patrick B. Thomas^2,3,4, Mahasha P. J. Perera^2,3,4,5, Saeid Alinezhad⁴, Andre Joshi^4,5, Paria Saadat², Clarissa Nicholls², Caitlin P. Devonport^2,4, Alivia R. Calabrese^2,3,4, Abby R. Templeton^2,3, Jack R. Wood², Nathan J. Mackenzie², Penny L. Jeffery^2,3,4, Ian Vela*^1,2,3,4,5, Elizabeth D. Williams*^1,2,3,4

¹School of Biomedical Sciences, Faculty of Health,Queensland University of Technology (QUT) at Translational Research Institute, ²Queensland Bladder Cancer Initiative (QBCI), ³Centre for Personalised Analysis of Cancers (CPAC), ⁴Australian Prostate Cancer Research Centre – Queensland, ⁵Department of Urology,Princess Alexandra Hospital

Chapters

00:04Introduction
00:48Generation of Bladder Tumor Organoids
06:57Results: Culturing of Patient-Derived Organoids for Translational Cancer Research
08:03Conclusion

Summary

Automatic Translation

患者来源的类器官（PDO）是转化癌症研究的有力工具，反映了疾病的遗传和表型异质性以及对个性化抗癌治疗的反应。在这里，详细描述了生成人类原发性膀胱癌PDO的合并方案，以准备评估表型分析和药物反应。

Tags

Bladder Cancer Organoids Precision Medicine Cancer Models Tumor Specimen Histopathological Analysis Molecular Analysis Cryopreservation

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