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癫痫小鼠模型中热诱发癫痫发作的行为筛查
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal
Neuroscience
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
Please note that all translations are automatically generated.
Click here for the English version.
癫痫小鼠模型中热诱发癫痫发作的行为筛查
DOI:
10.3791/62846-v
•
06:58 min
•
July 12, 2021
•
Antara Das
,
Martin A. Smith
,
Diane K. O’Dowd
1
Department of Developmental and Cell Biology
,
University of California
,
2
Department of Anatomy and Neurobiology
,
University of California
Chapters
00:04
Introduction
01:06
Preparation for the Heat-Induced Seizure Assay
02:36
Heat-Induced Seizure Assay
04:36
Results: Screening for Occurrence of Heat-Induced Seizures in Mice with the Different Genetic Backgrounds
06:17
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
该方法的目标是在小鼠模型中筛查热疗或热诱发的癫痫发作。该协议描述了使用定制的腔室,连续监测体温,以确定体温升高是否会导致癫痫发作。
Tags
Heat-induced Seizures
GEFS+ Mutations
Febrile Seizures
Digital Temperature Controller
Heating Box
Body Temperature
Potential Therapies
Rectal Temperature Probe
Anesthesia
Screening Assay
Body Weight
Recovery Cage
Core Body Temperature
Heat Chamber
Temperature Gradient
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