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一 种研究 并靶向乳腺癌脑转移性肿瘤生长的离体脑切片模型
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Cancer Research
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JoVE Journal Cancer Research
An Ex Vivo Brain Slice Model to Study and Target Breast Cancer Brain Metastatic Tumor Growth
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一 种研究 并靶向乳腺癌脑转移性肿瘤生长的离体脑切片模型

DOI:
10.3791/62617-v

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10:38 min

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September 22, 2021

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, , , , , , ,
1Department of Biochemistry and Molecular Biology,Drexel University College of Medicine, 2Department of Pharmacology and Physiology,Drexel University College of Medicine, 3Department of Radiation Oncology,Thomas Jefferson University, 4Sidney Kimmel Cancer Center,Thomas Jefferson University

Chapters

  • 00:04Introduction
  • 00:54Intracranial Tumor Cell Injection
  • 03:44Brain Slice Generation
  • 06:04IVIS Imaging of Slices
  • 07:40Results: Ex vivo Breast Cancer Brain Metastatic Tumor Growth
  • 10:08Conclusion

Summary

Automatic Translation

Automatic Translation

我们介绍了一种在有机结构脑切片模型中测量乳腺癌脑转移细胞的实时药物和辐射反应的方案。这些方法提供了一种定量测定法，以研究各种治疗对脑微环境界面内乳腺癌脑转移瘤的治疗效果。

Tags

Brain MetastasisEx Vivo Brain Slice ModelBreast CancerDrug Efficacy TestingTumor GrowthBrain-tumor-host InteractionsBrain Tumor Microenvironment

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