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由瞬态双边常见胡萝卜动脉闭塞引起的缺血性视网膜损伤的 Murine 模型
JoVE Journal
Medicine
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JoVE Journal
Medicine
A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Please note that all translations are automatically generated.
Click here for the English version.
由瞬态双边常见胡萝卜动脉闭塞引起的缺血性视网膜损伤的 Murine 模型
DOI:
10.3791/61865-v
•
05:20 min
•
November 12, 2020
•
Deokho Lee*
1,2
,
Yukihiro Miwa*
1,2,3
,
Heonuk Jeong
2
,
Shin-ichi Ikeda
2
,
Yusaku Katada
2
,
Kazuo Tsubota
2,4
,
Toshihide Kurihara
2
1
Laboratory of Photobiology
,
Keio University School of Medicine
,
2
Department of Ophthalmology
,
Keio University School of Medicine
,
3
Animal eye care
,
Tokyo Animal Eye Clinic
,
4
Tsubota Laboratory, Inc.
Chapters
00:04
Introduction
01:00
Transient Bilateral Common Carotid Artery Occlusion (tBCCAO)
03:12
Results: Analysis of Eyelid Drooping, HIF-1α Stabilization, Reactive Gliosis, Visual Dysfunction, and Change in Retinal Thickness After tBCCAO
04:40
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
在这里,我们描述了一个鼠标模型的视网膜缺血通过瞬态的双边常见的胡萝卜动脉闭塞使用简单的缝合线和夹子。该模型可用于了解心血管异常引起的视网膜缺血的病理机制。
Tags
Ischemic Retinal Injury
Transient Bilateral Common Carotid Artery Occlusion
Murine Model
Retinal Ischemia
Pathophysiology
Ischemic Retinopathies
In Vivo Drug Screening
Vascular Diseases
Diabetic Retinopathy
Occlusion Of Retinal Veins Or Arteries
Ocular Ischemic Syndrome
BALB/c Mice
Eyelid Drooping
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