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在大鼠中生成电机Tic表达的急性和慢性实验模型
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Behavior
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JoVE Journal Behavior
Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
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在大鼠中生成电机Tic表达的急性和慢性实验模型

DOI:
10.3791/61743-v

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07:38 min

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May 27, 2021

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, ,
1The Leslie & Susan Goldschmied (Gonda) Multidisciplinary Brain Research Center,Bar-Ilan University

Chapters

  • 00:04Introduction
  • 00:51Generation of Acute Experimental Model of Motor Tic Expression in a Rat
  • 02:38Generation of Chronic Experimental Model of Motor Tic Expression in a Rat
  • 04:32Implantation of Chronic Model (Osmotic Pump) into the Rat
  • 06:19Results: Tic Expression in Both Models
  • 07:11Conclusion

Summary

Automatic Translation

Automatic Translation

我们提出在行为自由的老鼠中生成急性和慢性抽搐表达实验模型的协议。模型基于纹状管管植入和随后的GABAA 拮抗剂应用。急性模型使用瞬时注射，而慢性模型则通过皮下植入的迷你渗透泵使用长时间输液。

Tags

Tic DisordersTourette SyndromeMotor TicsExperimental ModelRatSurgeryImplantationCannulaInjectionBicucullineInfusionChronicAcute

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