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Cancer Research
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乳腺癌临床前模型乳腺肿瘤的矫形移植
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Cancer Research
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Cancer Research
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Please note that all translations are automatically generated.
Click here for the English version.
乳腺癌临床前模型乳腺肿瘤的矫形移植
DOI:
10.3791/61173-v
•
07:45 min
•
May 18, 2020
•
Xiangdong Lv*
1,2,3
,
Lacey E. Dobrolecki*
1,2,3
,
Yao Ding
2,3
,
Jeffrey M. Rosen
2,3
,
Michael T. Lewis
2,3
,
Xi Chen
2,3
1
Department of Molecular and Cellular Biology
,
Baylor College of Medicine
,
2
Lester and Sue Smith Breast Center
,
Baylor College of Medicine
,
3
Dan L. Duncan Cancer Center
,
Baylor College of Medicine
Chapters
00:04
Introduction
01:22
Cryopreserved Mammary Tumor Fragment Preparation
02:23
Fresh Mammary Tumor Sample Collection and Preparation
03:28
Surgical Preparation
04:04
Tumor Fragment Transplantation
06:26
Results: Representative Transplant Tumor Characterization
06:54
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
患者衍生异种移植(PDX)模型和可移植的基因工程小鼠模型忠实地概括了人类疾病,是基础和转化乳腺癌研究的首选模型。在这里,一种方法被描述为正位移植乳房肿瘤片段到乳腺脂肪垫研究肿瘤生物学和评估药物反应。
Tags
Orthotopic Transplantation
Breast Tumor
Preclinical Model
Breast Cancer
Tumor Biology
Drug Response
Drug Resistance
Mammary Fat Pad
Patient-derived Xenograft
Subcutaneous Implantation
Cryopreservation
Thawing
Tumor Dissection
DMEM
Article
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