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Biology
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建模年龄相关的神经退行性疾病在
卡诺哈布迪蒂斯埃利根
JoVE Journal
Biology
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JoVE Journal
Biology
Modeling Age-Associated Neurodegenerative Diseases in
Caenorhabditis elegans
Please note that all translations are automatically generated.
Click here for the English version.
建模年龄相关的神经退行性疾病在
卡诺哈布迪蒂斯埃利根
DOI:
10.3791/61169-v
•
07:04 min
•
August 15, 2020
•
Konstantinos Palikaras
2
,
Nektarios Tavernarakis
2
1
Institute of Molecular Biology and Biotechnology
,
Foundation for Research and Technology-Hellas, Greece
,
2
Department of Basic Sciences, Faculty of Medicine
,
University of Crete, Heraklion, 70013, Crete, Greece
Chapters
00:00
Introduction
00:39
Necrotic Cell Death-induced by Hyperactive Ion Channels
04:06
Protein Aggregate-induced Neurodegeneration
05:58
Representative Results: Monitor Necrotic Cell Death-Induced by Hyperactive Ion Channels and Protein Aggregate-induced Neurodegeneration
06:30
Conclusion
Summary
Automatic Translation
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Automatic Translation
在这里,我们介绍和描述广泛的方法,利用一些多功能线虫模型,包括高活性离子通道诱导坏死和蛋白质聚合诱导神经毒性,以监测和解剖年龄相关的神经退行性疾病的细胞和分子基础。
Tags
Caenorhabditis Elegans
Neurodegenerative Diseases
Alzheimer’s
Parkinson’s
Huntington’s Disease
Protein Aggregates
Neurotoxicity
Necrosis
Nematode Culture
Heat Shock
L1 Larvae
Microscopy
Neurodegeneration
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