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大鼠关节内注射单碘乙酸酯诱导的骨关节炎疼痛模型
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Medicine
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JoVE Journal
Medicine
Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats
Please note that all translations are automatically generated.
Click here for the English version.
大鼠关节内注射单碘乙酸酯诱导的骨关节炎疼痛模型
DOI:
10.3791/60649-v
•
08:09 min
•
May 20, 2020
•
Jiaan Xu
2
,
Li Yan
2
,
Bo Yan
2
,
Li Zhou
,
Peijian Tong
,
Letian Shan
1
The First Affiliated Hospital
,
Zhejiang Chinese Medical University
,
2
College of Pharmaceutical Science
,
Zhejiang Chinese Medical University
Chapters
00:04
Introduction
00:47
Intra‐Articular Mono‐Iodoacetate (MIA) Injection
01:48
Mechanical Withdrawal Threshold (MWT)
03:00
Thermal Withdrawal Latency (TWL)
04:17
Gait Pattern Analyses
05:39
Results: Representative MIA Development and Characterization
07:16
Conclusion
Summary
Automatic Translation
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Automatic Translation
本研究描述了大鼠关节内注射单碘乙酸酯的方法,并讨论了由此产生的疼痛相关行为和组织病理学变化,为今后的应用提供参考。
Tags
Osteoarthritis
Pain Model
Mono-iodoacetate
Intra-articular Injection
Rats
Paw Withdrawal Threshold
Thermal Withdrawal Latency
Behavioral Testing
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