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Cancer Research
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用于转化免疫肿瘤学(I-O)研究的人类外周血单核细胞(PBMC)的人工化异种移植模型
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Cancer Research
A Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model for Translational Immuno-oncology (I-O) Research
Please note that all translations are automatically generated.
Click here for the English version.
用于转化免疫肿瘤学(I-O)研究的人类外周血单核细胞(PBMC)的人工化异种移植模型
DOI:
10.3791/59679-v
•
08:17 min
•
August 15, 2019
•
Zhuo Li*
1
,
Xiao Yang*
1
,
Yilu Zhang
,
Xiaolong Yang
,
Xinxin Cui
,
Yanjuan Zhang
,
Wenfeng Gong
,
Huichen Bai
,
Ning Liu
,
Zhiyu Tang
,
Mingming Guo
,
Kang Li
,
Tong Zhang
,
Lai Wang
,
Xiaomin Song
1
BeiGene (Beijing) Co., Ltd.
Chapters
00:04
Title
00:46
Cyclophosphamide Myeloablation and Human Peripheral Blood Mononuclear Cell (PBMC) Transplantation and Tumor Engraftment
02:08
Immunohistochemistry (IHC)
04:33
In Vivo Efficacy and Pharmacodynamics Analyses
06:08
Results: Representative PBMC- and Tumor-Engraftment and Anti-Tumor Antibody Treatment Analysis
07:16
Conclusion
Summary
Automatic Translation
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Automatic Translation
我们描述了人类外周血单核细胞(PBMC)–基于人体的异种移植小鼠模型,用于转化免疫肿瘤学研究。该协议可作为建立和描述类似I-O治疗评估模型的一般准则。
Tags
PBMC
Humanized Xenograft
Immuno-oncology
Myeloid Cell Depletion
Cyclophosphamide
Disulfiram
Tumor Growth
Immunohistochemistry
Antigen Retrieval
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