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Neuroscience
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通过对流增强的传递将抗体输送到毛里脑
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
Please note that all translations are automatically generated.
Click here for the English version.
通过对流增强的传递将抗体输送到毛里脑
DOI:
10.3791/59675-v
•
08:22 min
•
July 18, 2019
•
Michal Beffinger
,
Linda Schellhammer
,
Stanislav Pantelyushin
,
Johannes vom Berg
1
Institute of Laboratory Animal Science
,
University of Zurich
Chapters
00:04
Title
00:49
Step Catheter Preparation
02:29
Step Catheter Testing
04:46
Antibody Solution Convection-enhanced Delivery (CED) into the Murine Brain
06:34
Results: Representative CED Infusion Analyses
07:40
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
对流增强输送(CED)是一种通过直接灌注大量组织,使治疗药物有效输送到大脑的方法。该过程需要使用导管和优化的注射程序。该协议描述了一种将抗体送入小鼠大脑的CED方法。
Tags
Convection-enhanced Delivery
Antibody Delivery
Brain
Murine
Step Catheter
Blood-brain Barrier
Fused Silica Capillary
Cyanoacrylate Adhesive
Stereotactic Robot
Agarose Gel
Trypan Blue
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