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在肝炎症和纤维化环境中产生的肝细胞癌的致癌肝细胞诱导正交小鼠模型
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Cancer Research
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JoVE Journal Cancer Research
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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在肝炎症和纤维化环境中产生的肝细胞癌的致癌肝细胞诱导正交小鼠模型

DOI:
10.3791/59368-v

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00:06 min

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September 12, 2019

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, , , , , ,
1Department of Surgery,University of Missouri-Columbia, 2Ellis Fischel Cancer Center,University of Missouri-Columbia, 3Molecular Microbiology and Immunology,University of Missouri-Columbia

Chapters

  • 00:04Title
  • 00:50Liver Fibrosis and Cirrhosis Induction
  • 01:19T Antigen (T Ag)-Transgenic Hepatocyte Isolation
  • 03:48MTD2 Hepatocyte Inoculation
  • 05:22Results: Representative Progress MTD2 Tumor Development
  • 05:58Conclusion

Summary

Automatic Translation

Automatic Translation

在这里，我们描述了一个临床相关的肝癌小鼠模型的发展，概括了肝细胞癌（HCC）的典型免疫特征。

Tags

Hepatocellular CancerOrthotopic Mouse ModelHepatic InflammationFibrosisTumor ImmunologyTumor MicroenvironmentLiver CancerTumor PerfusionCollagenase DigestionTumor Implantation

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