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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice In Vivo
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
DOI:

00:07 min

August 23, 2019

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Chapters

  • 00:04Title
  • 00:49Flank Inoculation and Intratumoral AntagomiR Treatment
  • 02:23Tumor Growth Analysis
  • 03:10Thyroid Orthotopic Inoculation and Systemic AntagomiR Treatment
  • 05:05Results: Representative Effects of In Vivo MicroRNA Inhibition on Tumor Growth in Mice
  • 06:42Conclusion

Summary

Automatic Translation

Ce protocole décrit les modèles de souris xénogreffes et orthotopiques de la tumorigénèse thyroïdienne humaine comme plate-forme pour tester des traitements inhibiteurs à base de microARN. Cette approche est idéale pour étudier la fonction des ARN non codants et leur potentiel en tant que nouvelles cibles thérapeutiques.

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