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Neuroscience
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将γ-氨基丁酸 (GABA) 电泳到癫痫焦点中进行, 防止小鼠癫痫发作
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Please note that all translations are automatically generated.
Click here for the English version.
将γ-氨基丁酸 (GABA) 电泳到癫痫焦点中进行, 防止小鼠癫痫发作
DOI:
10.3791/59268-v
•
07:01 min
•
May 16, 2019
•
Andrea Slezia*
1,5
,
Christopher M. Proctor*
2,3
,
Attila Kaszas
4
,
George G. Malliaras
3
,
Adam Williamson
5
1
Aix Marseille Université, Institut de Neurosciences des Systèmes (INS)
,
2
Electrical Engineering Division
,
University of Cambridge
,
3
Department of Bioelectronics
,
Centre Microélectronique de Provence – Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE)
,
4
Institut de Neurosciences de la Timone
,
Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université
,
5
Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology
,
University of Szeged
Chapters
00:04
Title
00:56
Craniotomy
02:23
Multichannel Silicon Probe and Microfluidic Ion Pump (μFIP) Insertion
04:23
Seizure Induction
05:26
Results: Representative Multichannel Recording and Seizure Response Analysis
06:26
Conclusion
Summary
Automatic Translation
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Automatic Translation
癫痫研究的挑战是在经典治疗不足的情况下, 为患者开发新的治疗方法。使用一个新的协议--在植入药物输送系统的帮助下--我们能够通过将 GABA 的电泳传递到癫痫的焦点来控制麻醉小鼠的癫痫发作。
Tags
Electrophoretic Delivery
GABA
Epileptic Focus
Seizure Prevention
Microaerophilic Ion Pump
Drug Delivery
Neurological Diseases
Stereotaxic Frame
Silicon Probe
Hippocampus
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