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Cancer Research
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使用小鼠化疗引起的粘炎模型评估小肠损伤和适应的重要端点和增殖标记
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Cancer Research
Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Please note that all translations are automatically generated.
Click here for the English version.
使用小鼠化疗引起的粘炎模型评估小肠损伤和适应的重要端点和增殖标记
DOI:
10.3791/59236-v
•
07:05 min
•
May 12, 2019
•
Anna Billeschou
,
Jenna Hunt
,
Hannelouise Kissow
2
1
Department of Biomedical Sciences, Faculty of Health and Medical Sciences
,
University of Copenhagen
,
2
Novo Nordisk Foundation Center of Basic Metabolic Research, Faculty of Health and Medical Sciences
,
University of Copenhagen
Chapters
00:04
Title
00:32
5-Fluorouracil (5-FU) Mucositis Induction
01:09
5-Bromo-2 -Deoxyuridine (BrdU) Quantification and Tissue Collectio
02:42
BrdU Immunoreactive Cell Area Measurement
04:23
Crypt Depth Measurement
04:57
Results: Representative Small Intestine Injury Recovery Assessment
06:17
Conclusion
Summary
Automatic Translation
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Automatic Translation
在这里,我们提出了一个协议,建立重要的终点和小肠损伤和补偿性增殖,使用化疗引起的粘炎模型。我们演示了使用细胞周期特定标记和使用小肠道重量、墓穴深度和绒痛高度作为端点来检测增殖细胞。
Tags
5-Florauracil
5FU
Chemotherapy-induced Mucositis
Mouse Model
Small Intestinal Injury
Compensatory Hyperproliferation
BrdU Quantification
Histological Processing
Image Analysis
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