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Immunology and Infection
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诱导BALB/c小鼠药物诱导的自身免疫性肝炎研究其致病机制
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Immunology and Infection
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Immunology and Infection
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Please note that all translations are automatically generated.
Click here for the English version.
诱导BALB/c小鼠药物诱导的自身免疫性肝炎研究其致病机制
DOI:
10.3791/59174-v
•
11:36 min
•
May 29, 2020
•
Dominic Thomas
,
Ting Yu Wu
,
Merylin Cottagiri
,
Maeva Nyandjo
,
Dolores B. Njoku
2
1
Department of Anesthesiology and Critical Care Medicine
,
Johns Hopkins University
,
2
Department of Pediatrics and Pathology
,
Johns Hopkins University
Chapters
00:04
Introduction
02:04
Isolation of the S-100 Fraction of the Liver
03:36
Trifluoroacetylation of S-100
05:45
Determination of CD4+ T cell Immune Responses
07:26
Isolation of Infiltrating Immune Cells from Immunized Mice
09:27
Results: Cell Immune Responses
10:45
Conclusion
Summary
Automatic Translation
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Automatic Translation
我们描述了BALB / c小鼠中的体内免疫,转化性肝炎模型,可用于研究药物诱导的自身免疫性肝炎的发病机制,包括该疾病中看到的性别差异。我们将描述该模型如何使用体内和体外实验技术演示可重复的分析。
Tags
Drug-induced Hepatitis
Autoimmune Hepatitis
BALB/c Mice
Liver Disease
Cirrhosis
Idiosyncratic DILI
Immune-mediated Hepatitis
Anesthetic Hepatitis
Viral Hepatitis
Fibrosis
Diagnostic Tests
Pathogenic Mechanisms
Mouse Model
Liver Perfusion
Liver Homogenization
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