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立体定向移植人胶质瘤多形性移植小鼠细胞毒性免疫细胞模型的研究
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Immunology and Infection
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JoVE Journal Immunology and Infection
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
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立体定向移植人胶质瘤多形性移植小鼠细胞毒性免疫细胞模型的研究

DOI:
10.3791/57870-v

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11:15 min

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September 01, 2018

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, , , , ,
1INSERM, CNRS, Université d’Angers, Université de Nantes,CRCINA, 2Immunotherapy, Graft, Oncology,LabEx IGO, 3Hopital de Nantes,Hotel Dieu

Chapters

  • 00:01Title
  • 01:37Preoperative Effector Cells Preparation
  • 03:50Stereotactic Injection: Surgical Procedure
  • 07:33Representative Results
  • 09:50Conclusion

Summary

Automatic Translation

Automatic Translation

在这里, 我们提出了一项协议, 以制备和立体定向管理的异基因人淋巴细胞在 immunodeficient 小鼠携带原位人原发性脑肿瘤。本研究为 intrabrain 细胞免疫疗法的可行性和抗肿瘤疗效提供了概念验证。

Tags

Glioblastoma MultiformeCellular ImmunotherapyCytotoxic Immune CellsOrthotopic XenograftsStereotactic InjectionGBM-reactive Effector CellsNSG Mouse ModelTumor MicroenvironmentAdoptive Cell Transfer

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