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Journal
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Cancer Research
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高通量三维肿瘤球体药物筛选的生成
JoVE Journal
Cancer Research
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JoVE Journal
Cancer Research
Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening
Please note that all translations are automatically generated.
Click here for the English version.
高通量三维肿瘤球体药物筛选的生成
DOI:
10.3791/57476-v
•
05:54 min
•
September 05, 2018
•
Lesley Mathews Griner
,
Kalyani Gampa
,
Toan Do
,
Huyen Nguyen
,
David Farley
,
Christopher J. Hogan
,
Douglas S. Auld
,
Serena J. Silver
1
Oncology Drug Discovery: Molecular Pharmacology
,
Novartis Institutes for Biomedical Research
,
2
Chemical Biology and Therapeutics
,
Novartis Institutes for Biomedical Research
Chapters
00:04
Title
00:34
1536-Well 3D Tumor Spheroid and 2D Cancer Cell Line Culture and Detection Reagent Addition and Analysis
03:54
Results: Comparing 2D-
vs.
3D-Culture Compound Efficacy
05:30
Conclusion
Summary
Automatic Translation
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Automatic Translation
在各种疾病征兆中, 越来越多的生理相关模型被开发并实施到药物发现计划中。这里描述的新的模型系统展示了三维肿瘤球体如何在高通量1536井板系统中进行培养和筛选, 以寻找新的肿瘤药物。
Tags
3D Tumor Spheroids
Drug Screening
High-throughput
Cell Culture
Cancer Cell Lines
1536-well Plates
Spheroid Medium
Acoustic Dispenser
Cell Lysis Reagent
ATP Luminescence
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