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難聴の治療のためのトランス鼓膜ドラッグデリバリー
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Medicine
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JoVE Journal
Medicine
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Please note that all translations are automatically generated.
Click here for the English version.
難聴の治療のためのトランス鼓膜ドラッグデリバリー
DOI:
10.3791/56564-v
•
09:52 min
•
March 16, 2018
•
Kelly Sheehan*
1
,
Sandeep Sheth*
2
,
Debashree Mukherjea
,
Leonard P. Rybak
2
,
Vickram Ramkumar
1
Department of Surgery, Division of Otolaryngology
,
Southern Illinois University School of Medicine
,
2
Department of Pharmacology
,
Southern Illinois University School of Medicine
Chapters
00:04
Title
00:57
Auditory Brainstem Response (ABR)
01:59
Trans-tympanic Injection
03:55
Cochlea Dissection and Decalcification
04:38
Cryosectioning and Immunohistochemistry
07:37
Results: Representative Effects of Trans-tympanic Drug/Biologic Delivery to the Rat Cochlea
09:20
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
蝸牛にトランス鼓膜のルートを通じて医薬品の集中管理のための手法を提案します。この経路によるドラッグデリバリー シスプラチン化学療法剤の抗腫瘍効果と干渉しません。
Tags
Trans-tympanic
Drug Delivery
Ototoxicity
Antioxidants
Otoprotective Agents
Biological Reagents
Cochlea
Hearing Loss
Cisplatin
Auditory Brainstem Response
High-frequency Transducers
Tympanic Membrane
Insulin Syringe
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