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小鼠脑海绵体畸形的诱导及显微 CT 成像
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JoVE Journal Medicine
Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
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小鼠脑海绵体畸形的诱导及显微 CT 成像

DOI:
10.3791/56476-v

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05:12 min

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September 04, 2017

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, , , ,
1Lab of Cardiovascular Signaling,Centenary Institute, 2Faculty of Medicine, Sydney Medical School,University of Sydney, 3Department of Pharmacology, School of Basic Medical Sciences,Tianjin Medical University, 4Australian Centre for Microscopy & Microanalysis,University of Sydney

Chapters

  • 00:05Title
  • 00:57Induction of Cerebral Cavernous Malformations in Mouse Models
  • 01:38Sample Preparation for Micro-CT Scans
  • 03:15Micro-CT Scan of CCM in the Neonatal Mouse Brain
  • 03:57Results: Rendered 3-D Images Showing CCM Lesions in the Neonatal Mouse
  • 04:34Conclusion

Summary

Automatic Translation

Automatic Translation

本协议演示了在小鼠模型中诱导脑海绵状畸形的疾病, 并使用对比增强微计算机断层扫描来测量病变的负担。该方法提高了建立的小鼠模型的价值, 以研究脑海绵状畸形和其他血管性疾病的分子基础和潜在的疗法。

Tags

Cerebral Cavernous MalformationsNeonatal MiceMicro-CT Imaging4-HTParaformaldehydeLugol’s IodineBrain ImagingVascular Disease

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