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头孢哌酮治疗小鼠模型的临床相关的<em>艰难梭菌</em>应变R20291
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Immunology and Infection
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JoVE Journal Immunology and Infection
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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头孢哌酮治疗小鼠模型的临床相关的<em>艰难梭菌</em>应变R20291

DOI:
10.3791/54850-v

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06:51 min

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December 10, 2016

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, , ,
1Department of Population Health and Pathobiology,North Carolina State University College of Veterinary Medicine, 2Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center,University of North Carolina School of Medicine

Chapters

  • 00:05Title
  • 00:53Inoculation of Mice with Clostridium difficile
  • 03:22Enumeration of C. difficile from Mouse Fecal Content
  • 05:03Results: The Murine Model of C. difficile Infection Demonstrates Significant Weight Loss, Bacterial Colonization and Histopathological Changes in Infected Mice
  • 06:10Conclusion

Summary

Automatic Translation

Automatic Translation

该协议概述了使用临床相关和转听话应变，R20291 艰难梭菌感染（CDI）的头孢哌酮小鼠模型。临床疾病的监测， 艰难梭菌细菌枚举，毒素的细胞毒作用，并在小鼠模型中在整个CDI病理学改变强调在协议中详述。

Tags

Clostridium DifficileMouse ModelCefoperazoneSpore InoculumGavageAnaerobicDilutionEnumerationToxin CytotoxicityHistopathology

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