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脑Microslices的兴奋性刺激作为<em>在体外</em>中风模型
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JoVE Journal Medicine
Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke
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脑Microslices的兴奋性刺激作为<em>在体外</em>中风模型

DOI:
10.3791/51291-v

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07:00 min

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February 04, 2014

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, , ,
1School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute,The University of Newcastle, 2School of Health and Human Sciences,Southern Cross University, 3School of Medicine and Public Health,The University of Newcastle

Chapters

  • 00:05Title
  • 01:08Preparation of Microslices
  • 02:27Equilibration of Microslices
  • 03:46Excitotoxic Stimulation
  • 05:26Results: Viability of Microslices
  • 06:41Conclusion

Summary

Automatic Translation

Automatic Translation

我们已开发了可用于检查涉及兴奋性毒性介导的脑损伤的分子机制的脑切片的模型。这种技术产生可行的成熟的脑组织，并减少所需的实验动物数量，同时保持神经回路，细胞相互作用，和突触后车厢部分完好无损。

Tags

Brain MicroslicesIn Vitro ModelStrokeExcitotoxicityNeuropathologyIschemic StrokeCell CultureMolecular PathwaysBrain RegionsExcitotoxic StimulationInhibitors

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