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Journal
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Immunology and Infection
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人源化的小鼠模型来研究细菌感染瞄准微血管
JoVE Journal
Immunology and Infection
This content is Free Access.
JoVE Journal
Immunology and Infection
Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
Please note that all translations are automatically generated.
Click here for the English version.
人源化的小鼠模型来研究细菌感染瞄准微血管
DOI:
10.3791/51134-v
•
11:40 min
•
April 01, 2014
•
Keira Melican
2
,
Flore Aubey
2
,
Guillaume Duménil
2
1
INSERM U970
,
Paris Cardiovascular Research Centre
,
2
Faculté de Médecine Paris Descartes
,
Université Paris Descartes
Chapters
00:05
Title
01:26
Skin Graft
03:40
Infection
05:41
Organ CFU Counts
07:52
Results: Representative CFU Counts and Histologies of Infected Human Tissue
11:14
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
脑膜炎奈瑟氏菌
是感染血管人类特定的病原体。在这个协议中人类微血管被移植人体皮肤上免疫功能低下小鼠引入鼠标。菌粘附到广泛的人类血管,导致紫癜皮疹通常在人类病例观察到的血管损伤和发育。
Tags
Humanized Mouse Model
Neisseria Meningitidis
Bacterial Infection
Microvascular Damage
Sepsis
Vascular Leak
Purpuric Rash
Human Skin Graft
Human Dermal Microvessel
Anastomosis
In Vivo Model
Pathogenesis
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