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酪氨酸激酶抑制剂的临床前评价急性白血病的治疗
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JoVE Journal
Medicine
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Please note that all translations are automatically generated.
Click here for the English version.
酪氨酸激酶抑制剂的临床前评价急性白血病的治疗
DOI:
10.3791/50720-v
•
10:49 min
•
September 18, 2013
•
Sandra Christoph
2
,
Alisa B. Lee-Sherick
,
Susan Sather
,
Deborah DeRyckere
,
Douglas K. Graham
1
Department of Pediatrics
,
University of Colorado Anschutz Medical Campus
,
2
Department of Bone Marrow Transplantation
,
University Hospital of Essen
Chapters
00:05
Title
01:39
Phospho-protein Western Blot
03:02
Methylcellulose Assay
04:24
Evaluation of Phospho-protein Inhibition in vivo
05:39
Evaluation of Anti-leukemia Activity of TKIs in ALL Xenograft Models
08:13
Results: Biochemical and Functional Effects Mediated by TKIs
10:07
Conclusion
Summary
Automatic Translation
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Automatic Translation
受体酪氨酸激酶是异位表达在许多癌症和已被确定为在急性白血病的治疗靶点。此手稿描述为酪氨酸激酶抑制剂对急性白血病的治疗的临床前评价的有效策略。
Tags
Tyrosine Kinase Inhibitors
Acute Leukemia
Pre-clinical Evaluation
Receptor Tyrosine Kinases
NOD-SCID-gamma Mice
Bioluminescence Imaging
Clonogenic Assays
Pharmacodynamics
Target Inhibition
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