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Immunology and Infection
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糖尿病CD4の養子移入+ T細胞によるマウスの加速された1型糖尿病の誘導
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Immunology and Infection
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JoVE Journal
Immunology and Infection
Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Please note that all translations are automatically generated.
Click here for the English version.
糖尿病CD4の養子移入+ T細胞によるマウスの加速された1型糖尿病の誘導
DOI:
10.3791/50389-v
•
06:27 min
•
May 06, 2013
•
Gregory Berry
,
Hanspeter Waldner
1
Department of Microbiology & Immunology
,
Pennsylvania State University College of Medicine
Chapters
00:05
Title
01:11
Isolation of T Cells from Spleen and Lymph Nodes of BDC2.5 Mice
02:52
Fluorescence-activated Cell Sorting of Diabetogenic CD4+ T Cells from BDC2.5 Mice
04:28
Adoptive Transfer of Diabetogenic CD4+ T Cells from BDC2.5 Mice
05:12
Monitoring Recipient Mice for Hyperglycemia and T1D
05:36
Results: Adoptive T-cell Transfer
06:10
Conclusion
Summary
Automatic Translation
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Automatic Translation
私たちは、膵島抗原特異、プライマリーCD4 + T細胞の養子移入によって2週間以内に、マウスにおける1型糖尿病(T1D)を誘導するための再現可能な方法を提供する。
Tags
Accelerated Type 1 Diabetes
Adoptive Transfer
Diabetogenic CD4+ T Cells
NOD Mouse
Autoimmune Diabetes
T Cell Receptor BDC2.5
NOD.SCID Recipient
T1D Pathogenesis
Therapeutic Interventions
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