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从使用鸡蛋<em>血吸虫</em>作为<em>在体内</em>蠕虫引起的肺部炎症模型
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
DOI:

09:58 min

June 05, 2012

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Chapters

  • 00:05Title
  • 01:25Purifying Schistosoma mansoni Eggs
  • 04:00Intraperitoneal Sensitization with S. mansoni Eggs: Day 0
  • 04:34Intravenous Challenge with S. mansoni Eggs: Day 14
  • 05:06Experimental Harvest: Day 22
  • 07:06Preparation of Recovered Tissues
  • 07:53Results: Inflammatory Response to S. mansoni Infection
  • 09:31Conclusion

Summary

Automatic Translation

血吸虫卵是强有力的刺激T辅助2型(Th2细胞)的免疫反应,寄生虫感染的特点,哮喘和过敏性炎症。该协议利用S。血吸虫卵注射产生的CD4 Th2细胞因子诱导的炎症反应在肺,肺肉芽肿形成的特点,各地的鸡蛋,嗜酸性粒细胞和巨噬细胞替代激活。

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