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Neuroscience
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视神经横断:一个成人在中枢神经系统的神经元凋亡模型
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Please note that all translations are automatically generated.
Click here for the English version.
视神经横断:一个成人在中枢神经系统的神经元凋亡模型
DOI:
10.3791/2241-v
•
12:06 min
•
May 12, 2011
•
Mark M. Magharious*
1
,
Philippe M. D’Onofrio*
1
,
Paulo D. Koeberle
1
Department of Surgery
,
University of Toronto
Chapters
00:05
Title
01:22
Surgical Approach
05:59
Accessing the Optic Nerve
08:31
Closing and Recovery
09:35
Representative Results
11:27
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
视神经横断是一个成人中枢神经系统损伤的广泛使用的模型。视网膜神经节细胞的90%(视网膜神经节细胞),其轴突完全横断(干切断)干切断后14天之内死亡。这种模式很容易经得起实验操作和高度重现。
Tags
Optic Nerve Transection
Adult Neuron Apoptosis
Central Nervous System
Retinal Ganglion Cells
Optic Nerve
Axotomized
Apoptotic Neuronal Cell Death
CNS Model
Vitreous Chamber
Drug Delivery
Intraocular Injections
Short Interfering RNAs (siRNAs)
Plasmids
Viral Vectors
Superior Colliculus
Apoptotic Mechanisms
Neuronal Population
Cell Survival Quantification
Fluorescent Tracer
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