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デキストラン硫酸ナトリウム(DSS)を用いたマウス大腸炎モデル
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JoVE Journal
Biology
Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
Please note that all translations are automatically generated.
Click here for the English version.
デキストラン硫酸ナトリウム(DSS)を用いたマウス大腸炎モデル
DOI:
10.3791/1652-v
•
08:39 min
•
January 19, 2010
•
Caitlyn G. Whittem
,
Amanda D. Williams
,
Christopher S. Williams
1
Department of Cancer Biology
,
Vanderbilt University
,
2
Departments of Medicine and Cancer Biology
,
Vanderbilt University
Chapters
00:00
Title
00:34
Introduction
00:52
Injury-Repair Colitis Model
02:06
Harvesting the Colon
04:04
Processing as “Sausages” for Macroscopic Analysis of the Entire Colon
05:52
Making “Swiss Rolls for the Histological Analysis of Acute Colitis
07:00
Acute Colitis in the Dextran Sulfate Sodium Model
07:59
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
飲料水で投与デキストラン硫酸ナトリウム(DSS)は、急性大腸炎の確立されたマウス炎症性損傷モデルです。このプロトコルは、DSSの治療や組織の準備のための方法を概説します。
Tags
Murine Colitis Modeling
Dextran Sulfate Sodium (DSS)
Colitis
Ulcerative Colitis
Crohn’s Disease
Crohn’s Colitis
Abdominal Pain
Distention
Malabsorption
Diarrhea
Hematochezia
Mucus In Stool
Environment
Genetics
Epithelial Barrier Dysfunction
Inflammatory Bowel Disease
Animal Models Of Colitis
Low-molecular Weight Dextran Sodium Sulfate (DSS)
Epithelial Damage
Inflammatory Response
Acute Injury
Chronic Inflammatory Diseases
3% DSS In Drinking Water
Weight Loss
Bloody Stools
Diarrhea
Euthanized
Necropsy Dissected Colons
Microscopic Analysis
Macroscopic Analysis
Article
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